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61.
Giulio Costa Marco Montemurro Jérôme Pailhès 《International Journal of Mechanics and Materials in Design》2018,14(4):669-696
In this paper, the solid isotropic material with penalisation (SIMP) method for topology optimisation of 2D problems is reformulated in the non-uniform rational BSpline (NURBS) framework. This choice implies several advantages, such as the definition of an implicit filter zone and the possibility for the designer to get a geometric entity at the end of the optimisation process. Therefore, important facilities are provided in CAD postprocessing phases in order to retrieve a consistent and well connected final topology. The effect of the main NURBS parameters (degrees, control points, weights and knot-vector components) on the final optimum topology is investigated. Classic geometric constraints, as the minimum and maximum member size, have been integrated and reformulated according to the NURBS formalism. Furthermore, a new constraint on the local curvature radius has been developed thanks to the NURBS formalism and properties. The effectiveness and the robustness of the proposed method are tested and proven through some benchmarks taken from literature and the results are compared with those provided by the classical SIMP approach. 相似文献
62.
Marely G. Figueroa-Pérez Iza F. Pérez-Ramírez Octavio Paredes-López Candelario Mondragón-Jacobo 《International Journal of Food Properties》2018,21(1):1728-1742
This study aimed to determine the phytochemical profile and nutraceutical properties of nopal cladodes (Opuntia ficus-indica) at different stages of maturity. Medium-age cladodes showed the highest total saponins, phytosterols, and indigestible fiber, as well as the highest in vitro antioxidant capacity and digestive enzymes inhibitory activity. Furthermore, these cladodes presented the highest content of p-hydroxybenzoic acid, p-coumaric acid, rutin, narcissin, nicotiflorin, β-sitosterol, and sitosteryl-3-β-glucopyranoside, as well as several amino acids, organic acids, and fatty acids. Whereas young cladodes contained the highest concentration of condensed and hydrolyzable tannins. These results demonstrated that maturity affects the nutritional and nutraceutical properties of nopal cladodes. 相似文献
63.
Christine Vignon Christelle Debeissat Jrme Bourgeais Nathalie Gallay Farah Kouzi Adrienne Anginot Frdric Picou Philippe Guardiola Elfi Ducrocq Amlie Foucault Nomie Ravalet Louis-Rome Le Nail Jorge Domenech Marie-Christine Bn Marie-Caroline Le Bousse-Kerdils Emmanuel Gyan Olivier Herault 《International journal of molecular sciences》2020,21(22)
The bone marrow (BM) microenvironment plays a crucial role in the development and progression of leukemia (AML). Intracellular reactive oxygen species (ROS) are involved in the regulation of the biology of leukemia-initiating cells, where the antioxidant enzyme GPx-3 could be involved as a determinant of cellular self-renewal. Little is known however about the role of the microenvironment in the control of the oxidative metabolism of AML cells. In the present study, a coculture model of BM mesenchymal stromal cells (MSCs) and AML cells (KG1a cell-line and primary BM blasts) was used to explore this metabolic pathway. MSC-contact, rather than culture with MSC-conditioned medium, decreases ROS levels and inhibits the Nrf-2 pathway through overexpression of GPx3 in AML cells. The decrease of ROS levels also inactivates p38MAPK and reduces the proliferation of AML cells. Conversely, contact with AML cells modifies MSCs in that they display an increased oxidative stress and Nrf-2 activation, together with a concomitant lowered expression of GPx-3. Altogether, these experiments suggest that a reciprocal control of oxidative metabolism is initiated by direct cell–cell contact between MSCs and AML cells. GPx-3 expression appears to play a crucial role in this cross-talk and could be involved in the regulation of leukemogenesis. 相似文献
64.
Moschetti Michael Xu Alan Schuh Benjamin Hohenwarter Anton Couzinié Jean-Philippe Kruzic Jamie J. Bhattacharyya Dhriti Gludovatz Bernd 《JOM Journal of the Minerals, Metals and Materials Society》2020,72(1):130-138
JOM - Refractory high-entropy alloys (RHEAs) are potential candidate materials for use in next-generation nuclear reactors due to their excellent mechanical performance at high temperatures. Here,... 相似文献
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Carrara Gabriel R. Burle Leonardo M. Medeiros Dianne S. V. de Albuquerque Célio Vinicius N. Mattos Diogo M. F. 《电信纪事》2020,75(3-4):163-174
Annals of Telecommunications - Blockchain is a disruptive technology that relies on the distributed nature of the peer-to-peer network while performing an agreement, or consensus, a mechanism to... 相似文献
70.
Adriano do Nascimento Simões Samara Lopes de Almeida Cristine Vanz Borges Kelem Silva Fonseca Aurélio Paes Barros Júnior José Ricardo Tavares de Albuquerque Camila Renata Corrêa Igor Otavio Minatel Maria Aparecida dos Santos Morais Marla Silvia Diamante Giuseppina Pace Pereira Lima 《Journal of Food Biochemistry》2020,44(8):e13322